Tuesday, May 31, 2011 4:30 PM
Biomaterials: Porous, Reticulated PCPU Scaffold For Soft Tissue Repair
By Dr. Balakrishna Haridas, Ph.D.
By leveraging features such as material chemistry, and maximizing interconnected porosity in a biostable elastomeric scaffold, it is possible to produce desirable clinical outcomes, i.e., stable tissue in-growth, while at the same time limiting the extent of the foreign body response to prevent encapsulation or scar formation.
Fig.1: The Biomerix Biomaterial - Fully Reticulated and Crosslinked PCPU Scaffold Urethanes based on polycarbonate (PC) soft segments and aromatic isocyanate based hard segments have been shown to provide superior biostability, i.e., resistance to hydrolytic, oxidative, and enzymatic degradation in vivo 1-3 . These desirable characteristics of the solid forms of this class of polymers led to the development of a three-dimensional macroporous elastomeric, reticulated PolyCarbonate-P more...
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